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Medical Marijuana May Be Beneficial in Managing Alzheimer’s Disease

June is Alzheimer’s and Brain Awareness Month so we turn our spotlight on this insidious disease and how medical cannabis may help. While there is a wealth of information about Alzheimer’s Disease, treating it, living with a loved one coping with it, and helping those afflicted are continuing challenges. The Centers for Disease Control and Prevention is teaming up with the Alzheimer’s Association in the Healthy Brain Initiative. The American Association of Retired People also offers a free “Staying Sharp Brain Health Assessment” in June.

Warning Signs

Common signs of AD are often first noticed by the person affected. Memory changes as we age, but certain types of memory loss are not typical. The CDC offers these guidelines for early assessment. People with one or more of these 10 warning signs should see a doctor to find the cause. Early diagnosis gives them a chance to seek treatment and plan.

·        Memory loss that disrupts daily life: forgetting events, repeating yourself or relying on more aids to help you remember (like sticky notes or reminders).

·        Challenges in planning or solving problems: having trouble paying bills or cooking recipes you have used for years.

·        Difficulty completing familiar tasks at home, at work, or at leisure: having problems with cooking, driving places, using a cell phone, or shopping.

·        Confusion with time or place: having trouble understanding an event that is happening later or losing track of dates.

·        Trouble understanding visual images and spatial relations: having more difficulty with balance or judging distance, tripping over things at home, or spilling or dropping things more often.

·        New problems with words in speaking or writing: having trouble following or joining a conversation or struggling to find a word you are looking for (saying “that thing on your wrist that tells time” instead of “watch”).

·        Misplacing things and losing the ability to retrace steps: placing car keys in the washer or dryer or not being able to retrace steps to find something.

·        Decreased or poor judgment: being a victim of a scam, not managing money well, paying less attention to hygiene, or having trouble taking care of a pet.

·        Withdrawal from work or social activities: not wanting to go to church or other activities as you usually do, not being able to follow football games or keep up with what’s happening.

·        Changes in mood and personality: getting easily upset in common situations or being fearful or suspicious.

We turn to Organic Remedies’ Pharmacist, Nick Signorella for answers to how therapy with medical cannabis may help. “A lot of our treatment with Alzheimer’s has to do with symptom management. Specifically, marijuana can help with food intake, agitation, sleep, and overall mood.” Signorella adds, “THC can help to increase food intake, help with agitation at lower doses, improve sleep, and improve mood/depression at lower doses.”

AD symptoms that may respond to cannabis include, sleep problems, paranoia, anxiety, dysphoria, pain, poor appetite, and weight loss. Signorella says AD patients may live a better lifestyle by examining a medical marijuana therapy. “For example, THC can inhibit acetylcholinesterase through the CB1 receptor, which theoretically could help to minimize the decline in cognitive function.” Signorella goes deeper, “Additionally CB2 receptor levels are increased in Alzheimer’s patients. The anti-inflammatory effects from CBD activating the CBD2 receptor could help reduce inflammation and neurotoxicity associated with Alzheimer’s.”

Dosage

Signorella would advise AD patients to turn to the many newly created cannabis delivery options including tinctures and capsules. But, he says, “caution should be used with higher doses of THC as this can actually cause increased agitation and disorientation. In general, the starting dosage for agitation and sleep should be around 2.5-5mg of THC depending on experience. CBD on the other hand can help with agitation, typically at lower doses, usually starting around 5mg of CBD.”  He adds, “I would typically start with a 1:1 ratio of THC:CBD, around 2.5mg or 5mg of each. It would depend on the specific patient, but generally lower to moderate doses of both THC and CBD would be used.”

Searching for Answers

Evidence is not as robust for the treatment of Alzheimer’s, but there is some anecdotal evidence cannabis can be beneficial. Many of the mechanisms in the prescription drug donepezil, commonly used to treat AD, are similar. Signorella says, “overall cannabis can help to improve quality of life for both the patient and caregiver, while potentially help to manage disease progression as well.”

During this June Alzheimer’s and Brain Awareness month, remember your Organic Remedies pharmacist may be able to help!

More info: The Centers for Disease Control and Prevention (CDC) and the Alzheimer’s Association have created the Healthy Brain Initiative’s (HBI) State and Local Public Health Partnerships to Address Dementia: The 2018-2023 Road Map.

 

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Parkinson’s Research Shows Promise in Medical Marijuana Therapy

We’re always excited to provide new information on research into the medical use of cannabis. Now, there’s news on research into Parkinson’s disease and medical marijuana. Parkinson’s is a neurodegenerative brain disorder. Patients face the worst prognosis: there is no known cure for this debilitating disease. But, there is hope. The latest news from the Parkinson’s Foundation shows cannabis as a new treatment option. The Parkinson's Foundation announced the results of its medical cannabis and Parkinson's disease (PD) survey. The survey, Weeding Through the Haze: A Survey on Cannabis Use Among People Living with Parkinson's Disease in the U.S., was completed by 1,064 people with PD.

The survey asked specific questions about cannabis use ― from symptom management to motivation for use and side effects ― and questions for those who do not use cannabis and why. About a quarter of the respondents used cannabis within the previous six months. Less than 13 percent reported negative side effects from cannabis use. Interestingly, more than half of the respondents learned about cannabis use from the internet or from friends or other people with PD.

Organic Remedies is Helping Patients Find Answers

At Organic Remedies, we turn to our pharmacists when questions arise. PharmD Shannon Ye, from our Enola dispensary was pleased to see the new Parkinson’s Foundation study, but says: “Unfortunately, few of the patients I speak with inquire about how medical cannabis could help manage and alleviate the symptoms of Parkinson's disease.” The findings point to a different direction among Parkinson’s patients; they want to know what’s available to help them, but medical cannabis doesn’t always come to mind. “I am not surprised at this finding,” said Ye. “I can recall that the majority of initial patients I've spoken to who live with Parkinson's disease are unaware of key aspects of medical cannabis.  Many of these patients lack knowledge regarding the potential side effects and dosages of medical cannabis or may have learned from inaccurate or misleading sources.”

Parkinson’s Foundation Looking For Better Outcomes

"At a time when cannabis is legal in more states than ever before, we believe this survey provides new and critical information for the growing population of cannabis users who have Parkinson's disease," said James Beck, PhD, Senior Vice President and Chief Scientific Officer of the Parkinson's Foundation. "Ultimately, our goal is better outcomes for everyone living with Parkinson's disease and we're committed to tackling issues that are a priority for the PD community."

The survey results show that there is a knowledge gap among people living with PD, which may be impacting their decisions about cannabis use. More than half of the respondents were not provided any information on how to use cannabis such as dosage, type and frequency of use. More than 60% had not received a cannabis recommendation from a licensed doctor or provider and overall, 89 percent said cannabis was not a replacement for their PD prescription medication.

Organic Remedies’ Superior Patient Experience

Those numbers may surprise you if you are a patient of Organic Remedies. A full 60 percent did not get advice from a medical professional. We offer a superior relationship between the patient and pharmacist.

Ye says, “For new and current patients living with Parkinson's disease who have a medical marijuana certification, I highly encourage them to schedule a consultation.  As a pharmacist at Organic Remedies, my priority is in providing quality patient care and offering education and recommendations that may best accomplish my patients' treatment goals.”

Organic Remedies' Research with Philadelphia College of Osteopathic Medicine

Organic Remedies’ vision is to be a leader in the advancement of medical cannabis therapy through innovative genetic programs, patient-focused care, and clinical research to realize the full potential of marijuana to improve overall wellness.

Our mission is to improve the overall wellness of our patients by producing and dispensing affordable quality medical marijuana products while continuing the advancement of medical marijuana therapies through genetics, collaborative research, and superior patient care. Right now, our research with PCOM is well underway.

While not focused on Parkinson’s disease, the quality of life surrounding medical marijuana use is central to Organic Remedies’ scientific approach.

"As part of our research partnership with Organic Remedies, Philadelphia College of Osteopathic Medicine (PCOM) is investigating how quality of life may change in the year after patients initiate medical marijuana treatment," said Michelle Lent, PhD, associate professor of clinical psychology at PCOM. "Specifically, we are evaluating changes in their emotional, social, occupational, and physical functioning."

The Parkinson’s Foundation Conclusion

In the U.S., cannabis has become more widely available for medical and recreational use. Until now, there was insufficient data about the attitudes towards, and experiences with, cannabis use among those living with PD. This survey aims to address this disparity. The 1,064 survey respondents came from 49 states. The average age for respondents was 71, and the average time they have lived with Parkinson's is seven years.

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ORGANIC REMEDIES’ CUTS THE RIBBON ON COMPANY’S FIRST MEDICAL MARIJUANA DISPENSARY IN MISSOURI

New Dispensary Provides Safe, Effective Therapies for Cape Girardeau Patients Suffering with Serious Medical Conditions

CAPE GIRARDEAU, Mo. (April 6, 2021)- Organic Remedies, a medical marijuana cultivation and research organization based in southcentral Pennsylvania, is celebrating the upcoming opening of its first Missouri dispensary at 350 N. Kingshighway, Cape Girardeau. Organic Remedies President Eric Hauser, RPh., along with state and local dignitaries and medical marijuana advocates, cut the ceremonial ribbon during the Open House event on Tues., April 6 at 10:00 a.m., one of several special activities planned before the dispensary officially opens for business to patients.

"We are proud to bring our unique brand of patient-focused healthcare to the city of Cape Girardeau," said Eric Hauser, RPh., President, Organic Remedies. "Since 2018, we have been strongly focused on improving the health and wellness of patients through medical marijuana therapies, and we look forward to supporting Missouri patients who are struggling with serious health conditions. We are also committed to becoming a vital member of the thriving Cape Girardeau community by offering new employment opportunities, supporting local veterans’ organizations, participating in community outreach events, and giving back to our communities through charitable contributions."

The ribbon cutting ceremony kicked off several special events planned at the Cape Girardeau dispensary, including:

  • Morning of Wed., April 7, Organic Remedies plans to host an Open House for the area’s first responders, law enforcement and emergency officials with tours of the dispensary and information about the medicinal benefits of medical marijuana.
  • Afternoon of Wed., April 7, the new dispensary will be open to the area’s healthcare providers to tour the facility and learn more about medical marijuana products and the therapeutic benefits for patients.
  • Thurs., April 8, the company is planning to host a “Meet the Cultivators/Manufacturers” community event, where the public can learn first-hand about the medical marijuana industry from many of Missouri’s own marijuana cultivators and manufacturers.

The Cape Girardeau dispensary is expected to officially open for business mid-April. New patients can visit the company’s website at www.organicremediesmo.com to learn more about the services provided or schedule a free pharmacist consultation via phone. Once the dispensary is officially open for business, only patients with a valid Missouri Medical Marijuana card and their designated guests may enter the dispensary.

About Organic Remedies
Organic Remedies is a life science organization committed to improving the overall wellness of patients by producing and dispensing affordable quality medical marijuana products while continuing the advancement of medical marijuana therapies through genetics, collaborative research, and superior patient care. Based in Carlisle, Pa., Organic Remedies provides safe, effective medical marijuana therapies to patients in Pennsylvania and Missouri. Organic Remedies delivers a clinical approach for the utilization of medical marijuana that is patient-focused, collaborative and outcomes based.

CONTACT:
Robb Hanrahan
Public Relations
717-329-6264
R.Hanrahan@OrganicRemediesPA.com

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What is Cannabis?

Cannabis is a flowering herb believed to have originated in Central Asia but is now found globally. As early as 2700 BC, there is documented evidence that cannabis was used as a safe and effective therapeutic remedy. Between 1840 and 1900, European and American journals of medicine published more than 100 articles on the therapeutic use of cannabis. In fact, cannabis was part of the American pharmacopoeia until 1942, and is currently available by prescription in the Netherlands, Israel, and Germany.

There are several species of cannabis. Those that contain high levels of the psychoactive chemical THC are commonly known as “marijuana” and used in medicinal marijuana. Those with low levels of THC are harvested commercially worldwide as “hemp” for a variety of products, including rope, paper, and clothing.

There are more than 475 chemical compounds in the cannabis plant, including over 80 medicinal cannabinoids. The two most well-known cannabinoids are THC and CBD.

What is THC? (Tetrahydrocannabinol)

THC is the psychoactive chemical in marijuana. It is the one that gives marijuana its mind-altering reputation. However, it also offers numerous medicinal benefits. THC blocks pain signals from the brain, making it a highly effective pain reliever, especially for nerve-related pain.

THC Molecule Diagram

What is CBD? (Cannabidiol)

The best way to describe CBD is to say it is the opposite of THC. And it is. That is because CBD is an anti-psychoactive chemical. It counteracts the mind-altering properties of THC and provides balance. This is one of the reasons why the different forms of medicinal marijuana are so effective.

CBD is also a highly beneficial chemical. It reduces nausea and suppresses epileptic seizures. Arthritis patients gain measurable relief from its anti-inflammatory properties. CBD slows tumor and cancer cell growth in cancer patients, and it has proven to be effective in treatments for anxiety and depression.

Dosage Forms Available

VAPORIZATION

Medical marijuana can be inhaled via vaporization. There are numerous products to help facilitate this process, including portable vapes, stationary vaporizers, and dabbing instruments.

From a health standpoint, many studies comparing the difference between smoking and vaporizing reveal that there are substantial advantages associated with vaporization which include more efficient cannabinoid extraction and a decreased exposure to toxic elements such as carbon monoxide and tar, which are derived from smoking.

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Vaporizing Dry Herb

Vaporizers designed to heat the cannabis in its raw, bud form are known as dry herb vaporizers. Dry herbs of all sorts have been used for centuries for meditation, relaxation and medicinal purposes. Certain flowers and herbs (including cannabis) can be dried, crushed and then inserted into a vape pen that is dry-herb capable. The vape’s oven chamber will heat up the dry herbs which will release a vapor which can then be inhaled. To get the most out of your vaporization experience, be sure to grind your material using an herb grinder to break your material down to create more surface area for the heat to reach.

TINCTURE

Tinctures are oils derived from the cannabis plant and are typically administered sublingually under the tongue with a dropper. This allows the cannabinoids to immediately enter the bloodstream through the vessel-rich tissues within the sublingual cavity. There are a large number of blood vessels under the tongue and within the mouth which can absorb cannabinoids, so that before you swallow, cannabis can also enter the blood stream.

Sublingual delivery through the oral mucosal membranes in your mouth is an effective way to ingest cannabinoids. This method provides for rapid and effective absorption directly into systemic circulation because of the increased bioavailability of the cannabinoids.

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RSO -RICK SIMPSON OIL

RSO is named after its creator, Rick Simpson, who became well-known for professing his passion for this type of product and its medical efficacy. RSO is produced using a vacuum distillation process, which distills out the solvent and reserves terpenes that would otherwise be lost to open air distillation. RSO is a great option for patients who do not want to vaporize or are uncomfortable swallowing capsules. Used orally, RSO can be absorbed through the mouth sublingually, or swallowed and ingested.

RSO

CAPSULES

Infused capsules are swallowed and absorbed through the gastrointestinal tract for slow onset and long-lasting effects. Capsules are precision dosed with a super-critically extracted marijuana concentrate which has been winterized and infused with coconut butter prior to filling. They are available in multiple formulations, giving patients the ability to select the option that is best for them.

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Edibles

Marijuana edibles can be brownies, cookies , pasta, and more. Any recipe that calls for butter or oil can be readily infused with cannabis. Edible cannabinoids are processed differently than inhaled cannabinoids. When it is ingested, cannabinoids enter the bloodstream through the stomach and liver, which increases potency and delays the onset of effects. Dosing should be carefully considered as an edible experience can be much stronger and last longer than other delivery methods. Effects could take up to three hours to absorb into the body.

Edibles

LOTIONS

Cannabinoids can also be absorbed through the skin. Products designed for this are known as cannabis topicals. The skin has a relatively complex absorption process that involves a chemical’s ability to dissolve in H20. Examples of topical products include lotions, creams, and balms. The topical application of cannabinoids has an onset of action within minutes locally (i.e. creams and balms applied to a joint), with duration of these effects lasting approximately one to two hours.

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CONcENTRATES/EXTRACTS

Cannabis concentrates, commonly referred to as cannabis extracts, are significantly more potent than your standard cannabis buds. Their applications as medicine have proven to be effective for patients suffering from many adverse health conditions. A cannabis concentrate is reminiscent of the cannabis strain it was extracted from; the smell, taste, and effects are simply magnified due to a larger concentration by weight.

Due to these products being a concentrated mix, you have the benefit of only needing a very small amount to get the same effect as you would with larger amounts of a less concentrated mix.

While the number of components released depends on the compounds present and the temperature, none of the toxic biproducts of smoking plant matter is present in the vapor. This means that vapor will have a much higher percentage of desired cannabinoid /terpenoid content when compared to smoke.

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Live Sugar – a shimmery crystalline concentrate made using the fresh-frozen material.

Budder – a smooth and creamy concentrate that resembles peanut butter in consistency.

Wax – a concentrate that easily breaks apart into smaller-sized pieces. Easy to work with using only your hands.

Live Budder – a smooth and creamy concentrate made using the fresh-frozen material.

Shatter – a translucent, glass-like concentrate that ‘shatters’ when tapped on a hard surface.

Terpenes

The cannabis plant consists of a wide variety of chemicals and compounds. About 140 of these belong to a large class of aromatic organic hydrocarbons known as terpenes (pronounced tur-peens).

Terpenes have been found to be essential building blocks of complex plant hormones and molecules, pigments, sterols, and cannabinoids. Terpenes are responsible for the pleasant, or not so pleasant, aromas of cannabis and the physiological effects associated with them. Although not permitted in Pennsylvania, patients will often ask to smell the cannabis when selecting their medicine. The idea is that certain aromas help identify different strains and their effects. Strains with relatively high concentrations of specific terpenes are easier to identify by their smell.

For example, the smell of musk or of clove is detected when there is a high level of the terpene myrcene. A piney smell is usually indicative of a high level of the terpene pinene and a lemony smell indicates a high level of the terpene limonene. Our online menu provides the terpene content, if available, of each product which may vary by batch and grower even for the same strain.

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NEW EASY PRODUCT ORDERING!

We have upgraded our online Product Reservation process!

NEW FEATURES:

  • Easy and user friendly.
  • Create a user account so you can always view your past ordersand easily reserve the same products.
  • Sort and search for products by grower, by form, THC/CBD and by price.
  • Product Menu automatically updated in real time- so the products you see on our menu are the products currently in stock.
  • Awesome product images and descriptions that includes theterpenes profile for the products you are ordering.
  • Place your products in your shopping cart and check out.
  • Text notifications to let you know your order has been receivedand when it's ready to pick up.
  • Choose a pick up time to streamline the process (Reservationswill be held for 24 hours).
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ORGANIC REMEDIES RECEIVES OPERATIONAL APPROVAL FOR CLINICAL REGISTRANT LICENSE

To our valued patients and caregivers,

We are pleased to announce that we have converted our Pennsylvania Medical Marijuana Dispensary license to a Clinical Registrant license. While this designation does not change our patient services or products, it allows us to partner with Philadelphia College of Osteopathic Medicine (PCOM) in conducting long-term research in the study of therapeutic applications of medical marijuana.

Initially, this research will focus on chronic pain and opioid management, the drug’s impact on behavioral health and quality of life, and trends in usage. We believe this is an important step toward defining the medicinal value of this plant-based therapy to enrich the lives of Pennsylvanians and humanity as a whole.

As a state-approved clinical registrant, Organic Remedies is now licensed to grow and process medical marijuana and open three additional medical marijuana dispensaries. Our current medical marijuana dispensaries in Enola, Chambersburg and York have now been converted to clinical registrant dispensaries.

We are looking forward to expanding our footprint in Pennsylvania to serve more patients through our personal, high-touch, clinical approach and developing our own line of medical marijuana products. We anticipate launching our own Organic Remedies product line later this year.

As a clinical registrant, there may be an opportunity for our current patients to participate in our upcoming clinical research if they meet specific criteria established for the clinical trials. We will keep you informed of the next step in the patient selection process as more information becomes available.

We thank you for your support as we continue to work together to more fully understand medical marijuana’s therapeutic applications and improve patients’ lives.

Sincerely, Organic Remedies Leadership Team

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ORGANIC REMEDIES GETS STATE APPROVAL AS A CLINICAL REGISTRANT

February 24, 2020

PHILADELPHIA COLLEGE OF OSTEOPATHIC MEDICINE AND ORGANIC REMEDIES PARTNER TO RESEARCH THERAPEUTIC BENEFITS OF MEDICAL MARIJUANA

The partners will be part of the states first-in-the-nation research program for medical marijuana.

 

CARLISLE, Pa. (Feb. 24, 2020) - Philadelphia College of Osteopathic Medicine (PCOM) and Organic Remedies are pleased to announce a strategic partnership dedicated to health outcomes-based research involving cannabinoids and medical marijuana. PCOM and Organic Remedies have signed a long-term research agreement to study therapeutic applications of medical marijuana. Initially, their research will focus on chronic pain and opioid management, the drug’s impact on behavioral health and quality of life, and trends in usage.

“Pennsylvania remains at the forefront of clinical research on medical marijuana. We, at PCOM, in partnership with a best-in-class clinical registrant partner, Organic Remedies, will collaborate with other academic clinical research centers to increase the pace of discovery,” said Jay S. Feldstein, DO, president and chief executive officer, PCOM. “Only through research will we more fully understand medical marijuana’s therapeutic applications and improve patients’ lives.”

PCOM has been approved as a certified Academic Clinical Research Center under Pennsylvania's Medical Marijuana law since September 2018.

As a state-approved clinical registrant, Organic Remedies will be licensed to grow and process medical marijuana and open three additional medical marijuana dispensaries. The organization currently operates three medical marijuana dispensaries in Enola, Chambersburg and York, Pa.

“Organic Remedies is honored to have the opportunity to work with such an esteemed institution as PCOM,” said Organic Remedies CEO Mark Toigo. “This is an important step toward defining the medicinal value of this plant-based therapy to enrich the lives of Pennsylvanians and humanity as a whole. We look forward to expanding our footprint in Pennsylvania to serve more patients by leveraging our patient-centric, personal, high-touch, clinical approach to patient care.”

The goal of the partnership between Organic Remedies with expertise in growing, processing and dispensing the highest quality medicinal marijuana, and PCOM known for its standard of excellence in patient care, education and research, is to identify which patients will benefit from the drug.

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About Philadelphia College of Osteopathic Medicine

Founded in 1899, Philadelphia College of Osteopathic Medicine has trained thousands of highly competent, caring physicians, health practitioners and behavioral scientists who practice a “whole person” approach to care—treating people, not just symptoms. PCOM offers doctoral degrees in clinical psychology, osteopathic medicine, pharmacy, physical therapy and school psychology, and graduate degrees in biomedical sciences, forensic medicine, mental health counseling, organizational development and leadership, physician assistant studies, school psychology, and public health management and administration. Our students learn the importance of health promotion, research, education and service to the community. Through its community-based Healthcare Centers, PCOM provides care to medically underserved populations in inner city and rural locations. For more information, visit www.pcom.edu

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About Organic Remedies

Organic Remedies provides safe, effective medical marijuana therapies to patients in South Central Pennsylvania. With three dispensaries, located in Enola, Chambersburg and York, Pa., Organic Remedies delivers a clinical approach for the utilization of medical marijuana that is patient focused, collaborative and outcomes based. An expert team of healthcare professionals is dedicated to helping patients with longstanding serious medical conditions who have failed to find adequate relief through other therapies.

 

FOR MORE INFORMATION, PLEASE CONTACT:

Janice Spurlock
Communications/Marketing
717-819-3895
J.Spurlock@OrganicRemediesPA.com